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Ce médicament fait l’objet d’une surveillance supplémentaire qui permettra l’identification rapide de nouvelles informations relatives à la sécurité. A magnetic resonance imaging (MRI) scan of the sinuses creates detailed pictures of the air-filled spaces inside the skull. Aripiprazole (Abilify) is an atypical antipsychotic used to treat different mental health conditions, such as schizophrenia and bipolar I. Depakote and Depakene come in different dosage forms with different usages. Generic Depakote (termed divalproex sodium) is available under several other names. 0 out of 10 from a total of 64 ratings on Drugs 52% of reviewers reported a positive. Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S 26 It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century Yes, Depakote XR 500 Tablet can cause damage to the liver. Topic: Medication Issues. By clicking "TRY IT", I agree to receive newsletters. Some of the most common ones are nausea and vomiting, headache, and drowsiness. Absence seizures: The starting Depakote dosage is 15 mg/kg of body weight per day. Oct 12, 2023 · Depakote and Depakote ER treat epilepsy, migraine, and bipolar disorder. Divalproex ER (Depakote ER) is an expensive drug used to prevent seizures caused by some forms of epilepsy. The Naranjo algorithm was used to assess whether a change in clinical status was the result of an adverse. Depakote ER is a medication used to treat seizures, migraines, and bipolar disorder. • Depakote is administered orally in divided doses. It is available in brand and generic versions. You should avoid or limit the use of alcohol while being treated with divalproex sodium. However, in some cases it may be the only treatment option available, for example, for. Most of the time, liver problems happened within the first 6 months after starting Depakote (divalproex sprinkle capsules). feeling of warmth or heat. It can also be used to treat bipolar disorder. It can also be used to treat bipolar disorder. Depakote mixed with alcohol can lead to extreme depression of the CNS, which manages brain-to-organ communication within the body. There are multiple forms of Depakote available in the US, but only one is approved for the treatment of bipolar disorder mixed/manic episodes. If you have difficulty swallowing capsules or tablets, view this article. Depakote for Migraine Prevention User Reviews. A masked music producer and activist named OUTLAW is driving around England giving out free weed and toilet paper to local residents on lockdown. Despite significant teratogenic risks, sodium valproate is still widely prescribed in many countries to women of childbearing age, as a mood stabiliser in bipolar disorder and also in epilepsy. [ 1] Valproate provides an advantage of fewer troublesome adverse effects than older. Learn about Depakote medication including the uses of depakote for bipolar disorder, epilepsy and migraines. Dec 11, 2023 · No matter the Depakote form you’re taking for seizures, the recommended dosage is the same and is calculated based on your body weight: Complex partial seizures: The starting Depakote dosage is between 10 mg/kg and 15 mg/kg of body weight per day. Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep. Pakai Halodoc kapan & dari mana saja. You should avoid or limit the use of alcohol while being treated with divalproex sodium. headache. The severity of hepatotoxicity can range from reversible hepatic dysfunction to irreversible liver failure. * This active drug is also available as a generic medication. Applies to: Depakote (divalproex sodium) Alcohol can increase the nervous system side effects of divalproex sodium such as dizziness, drowsiness, and difficulty concentrating. The information was leaked from an internal source. Please see Important Safety Information & Boxed Warning When taken with Depakote it can cause some very serious drug interactions. Depakote Sprinkles side effects. You could have more side effects. 2. Clinically, it's used to manage manic episodes associated with bipolar disorder, prevent migraines, treat seizures, and occasionally, certain types of anxiety. Depakote ER has an average rating of 7. Feeling dizzy, drowsy, and unsteady. simple and complex absence seizures, with or without other seizure types. Depakote has an average rating of 6. Good luck!!🍀 Reply reply More posts you may like r/Epilepsy The mission of r/epilepsy is to provide a community forum for people who are affected by epilepsy Note: "Valproate" includes the following preparations: divalproex sodium (Depakote® or Depakote-ER®), valproic acid (Depakene®), sodium valproate (Depakene® syrup), valproate sodium injection (Depacon®). Includes dosages for Migraine Prophylaxis, Epilepsy and Mania; plus renal, liver and dialysis adjustments. Even if other drugs have failed, they could be administered off-label for anxiety. Depakote (divalproex sodium) is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches. These symptoms may appear in varying combinations and levels of. Depakote® – FDA-approved medication for patients with acute bipolar mania & epilepsy. CSA Schedule ** View glossary of terms Is depakote an maoi. Learn more about Depakote warnings, interactions, and alternatives. Some people, especially the elderly, may also experience impairment in thinking. Depakote ER allows for once-daily dosing, and sprinkle capsules allow Depakote to be mixed into soft food such as applesauce, yogurt, pudding, oatmeal, or ice cream. Depakote treatment is usually initiated at a dosage of 10-15 mg/kg/day. Valproic acid has an average rating of 6. The most commonly reported interactions are convulsions, deep vein thrombosis and respiratory failure. divalproex sodium topiramate. affecting GABA activity. • Epilepsy Complex Partial Seizures in Adults and Children 10 years of age or older: Initial dose is 10 to 15 mg/kg/day, increasing at 1 week intervals by 5 to10 mg/kg/day to achieve optimal clinical response. Divalproex is the generic version of Depakote. A manic episode is a distinct period of abnormally and persistently elevated, expansive, or irritable mood. I gained 25 pounds in the first two weeks of taking it. Please visit Depakote. Applies to: Depakote (divalproex sodium) Alcohol can increase the nervous system side effects of divalproex sodium such as dizziness, drowsiness, and difficulty concentrating. More about Depakote ( divalproex sodium ) Ratings & Reviews. If you have difficulty swallowing capsules or tablets, view this article. I'm absolutely floored with how quickly and well depakote works for me. Feeling dizzy, drowsy, and unsteady. Epilepsy is a neurological disorder characterized by recurrent seizures. Depakote has an average rating of 6. Maximum dose: 60 mg/kg daily. Depakote digunakan secara oral (melalui mulut) seperti yang diarahkan oleh dokter. It is an effective and well-tolerated treatment that offers new hope for patients. It comes in the form of tablets, syrups, and capsules. Divalproex sodium is an anticonvulsant used to treat seizures, bipolar disorder and migraine headaches. Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S 26 It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century Yes, Depakote XR 500 Tablet can cause damage to the liver. See also: Generic Depakote. • Depakote is administered orally in divided doses. "I take 2500mg Depakote per day for rapid cycling bipolar disorder and it works very well. This means that every 9 to 16 hours, half of the previous amount of Depakote in the body is removed. Depakote 1000 MG Tablet is a prescription medicine that contains Divalproex. Facts • Depakote is available in: - Liquid and tablets (depending on the form given, Depakote should be taken one to four times a day as prescribed) • This medicine works by decreasing: - Mood swings Depakote Sprinkle Capsules are administered orally. Welcome to another episode of The TechCrunch. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. If you are a female able to have a baby, you must use an effective method of birth control (contraception) at all times during your entire treatment with Depakote. Learn more about Depakote's dosage, interactions, and precautions. straight flight It can also be used to prevent migraines and treat bipolar disorder. Oct 17, 2023 · Divalproex Sodium The active ingredient in Depakote changes in the body to valproate (val-PRO-ate), so you may also see this name used if you read about Depakote. Medscape - Seizures, mania, and migraine prophylaxis dosing for Depakote (divalproex sodium), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Valproic acid side effects. 5 equivalent of sodium hydroxide. Depakote has interactions with some other drugs and certain supplements. frequent urge to urinate. Common side effects of Depakote include upset stomach, constipation or diarrhea, nausea, and headache. Epilepsy is a seizure disorder that affects part of or the entire brain and can have very noticeable symptoms. These symptoms may appear in varying combinations and levels of. Valproic acid is not suitable for girls or women who could become pregnant. Within the therapeutic ranges listed above, most patients experience therapeutic drug effects without excessive side effects. Depakote and Depakene come in different dosage forms with different usages. Depakote is an anticonvulsant drug used to treat bipolar disorder, epilepsy, and migraine headaches. Mar 5, 2023 · The starting dosage of Depakote ER tablets is 25 mg per kilogram* of body weight per day (25 mg/kg/day). Learn more about Depakote's dosage, interactions, and precautions. [ 1] Valproate provides an advantage of fewer troublesome adverse effects than older. jim castillo phillips husband However, get medical help. Depakote may be used in the treatment of epilepsy and mania, and to prevent migraines; however, people taking Depakote should be monitored for potentially fatal side effects such as liver failure Prescription only. Valproic acid is an anticonvulsant used to treat epilepsy, bipolar disorder and migraine headaches. The maximum recommended dosage is 60 mg/kg/day (22). A Malibu estate belonging to actor and filmmaker Mel Gibson is now on the market for $17. these reactions are estimated to occur in 1 to 6 per 10,000 new users in countries with mainly caucasian populations, but the risk in some asian. Introduction. Applies to: Depakote (divalproex sodium) Alcohol can increase the nervous system side effects of divalproex sodium such as dizziness, drowsiness, and difficulty concentrating. BRAND NAME(S): Depakote. O divalproato de sódio é dissociado em íon valproato no trato gastrointestinal. We inherently have this fear of being known, but still want to be loved, be happy, and successful in what we do. Divalproex sodium is also used to treat the manic phase of bipolar disorder (manic-depressive illness) and helps prevent migraine headaches. Valproic acid (VPA) is an anticonvulsant drug used to treat bipolar disorder, epilepsy, and migraines [1]. Depakote (divalproex sodium) is a valproate and is indicated for the treatment of the manic episodes associated with bipolar disorder. It is also used to treat bipolar mania and to prevent migraine headaches. 4 out of 10 from a total of 98 ratings on Drugs 65% of reviewers reported a positive effect, while 12% reported a negative effect. Valproic acid (VPA) is an anticonvulsant drug used to treat bipolar disorder, epilepsy, and migraines [1]. air fry oven recipes Learn about the typical dosages, strengths, and forms of Depakote and Depakote ER, two anticonvulsant drugs used to treat seizures, migraine, and bipolar disorder. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. By controlling the frequency of seizures, it will help you go about your daily activities with more confidence. Notify HCP if patient has suicidal thoughts, and yellowing of skin and eyes. Systemic lupus erythematosus. Some of the most common ones are nausea and vomiting, headache, and drowsiness. Depakote package insert / prescribing information for healthcare professionals. Learn about Depakote medication including the uses of depakote for bipolar disorder, epilepsy and migraines. Divalproex sodium is also used to treat the manic phase of bipolar disorder (manic-depressive illness) and helps prevent migraine headaches. On April 27, Merit Medical Sys. The interaction can be minor to life threatening. The choice between these formulations depends on various factors, such as your individual needs, preference, and treatment goals.
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Depakote ER allows for once-daily dosing, and sprinkle capsules allow Depakote to be mixed into soft food such as applesauce, yogurt, pudding, oatmeal, or ice cream. Carsmateos 8 Jan 2018. Si vous avez ce type de pensées, contactez immédiatement votre médecin. Depakote is available in two formulations: extended-release (ER) and delayed-release (DR). Jan 8, 2022 · The side effects in the sections below are based on clinical trials of Depakote DR tablets, Depakote ER tablets, and Depakote DR sprinkle capsules. Divalproex sodium is also used to treat the manic phase of bipolar disorder (manic-depressive illness) and helps prevent migraine headaches. Valproic acid-induced hyperammonemic encephalopathy may occur in people with normal liver function, despite normal doses and serum levels of VPA. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Brand names: Valproate Sodium. Indices Commodities Currencies Stocks Getting accurate measurements for inside corners is easier than you may think. We present a case of valproic acid-induced thrombocytopenia associated with spontaneous systemic bleeding. Depakote should be swallowed whole and should not be crushed or chewed (22). Below is a text only representation of the Patient Information Leaflet (ePIL). In addition, VPA is useful in bipolar disorder, migraine headache, and diabetic neuropathy-related pain. Includes dose adjustments, warnings and precautions. Don't suddenly stop taking this medication since it can raise your risk of withdrawal symptoms, including seizures. If stomach upset occurs, you can take it with food. Depakote tablets should be swallowed whole and should not be crushed or chewed. blippi clothes Depakote Sprinkle Capsules can cause serious side effects including: Bleeding problems: red or purple spots on your skin, bruising, pain and swelling into your joints due to bleeding or bleeding from your mouth or nose. Despite significant teratogenic risks, sodium valproate is still widely prescribed in many countries to women of childbearing age, as a mood stabiliser in bipolar disorder and also in epilepsy. You should avoid or limit the use of alcohol while being treated with divalproex sodium. What is the recommended Depakote dosage. According to WebMd, Depakote is an oral medication that is used to treat some psychiatric conditions, such as the manic phase of bipolar; seizure disorders; and even as a migraine preventative. Depakote is also approved to treat bipolar disorder as well. Sep 30, 2017 · The originals were larger and white and had a different stamp on them. Depakote ER allows for once-daily dosing, and sprinkle capsules allow Depakote to be mixed into soft food such as applesauce, yogurt, pudding, oatmeal, or ice cream. dose cold turkey with no adverse effects. Depakote, also known by its generic name, divalproex sodium, is a medication primarily used to treat epilepsy and bipolar disorder. Valproic acid is a broad-spectrum antiseizure drug with a narrow therapeutic window. These drug interactions can make your medication less effective or worsen side effects. You can find detailed information about this drug in the official Patient Information Leaflet (PIL). to treat manic episodes associated with bipolar disorder. Find out how it can help you manage your symptoms. Check depakotewert. In these cases, various add‐on medications are used, and valproate is one of these. It is available in brand and generic versions. Depakote should be swallowed whole and should not be crushed or chewed (22). Includes dose adjustments, warnings and precautions. Suggested nonpharmacologic interventions for use in patients with Alzheimer's disease are provided in Table 2. I think I stopped my Depakote for at least 5 days not on purpose just having lost time episodes diphenhydrAMINE divalproex sodium. Study with Quizlet and memorize flashcards containing terms like Depakote: Generic Name, Depakote: Category, Class, Depakote: Indication and more. minecraft realms bedrock codes Valproic acid (VPA) ia as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders. This medicine is an anticonvulsant that works in the brain tissue to stop seizures. 0 tablets) uses, composition, side-effects, price, substitutes, drug interactions, precautions, warnings, expert advice and buy online at best price on 1mg. It can also be used to prevent migraines and treat bipolar disorder. It comes in the form of tablets, syrups, and capsules. May 30, 2023 · Depakote (divalproex sodium, sodium valproate, and valproic acid) is an anticonvulsant (anti-seizure) medication used as a mood stabilizer in treating bipolar disorder. According to the 2005 Annual Report of the American Association of Poison Control Center's Toxic Exposure Surveillance System (TESS), 8705 acute exposures to valproic acid occurred with major adverse outcomes reported in 404 patients of this cohort. Learn about its dosage, interactions, side effects, warnings, and alternatives from GoodRx. I'm just starting out, but I'm up to 1000mg/day of the ER form taken in the morning as instructed. flushing or redness of the skin, especially on the face and neck. It will have been given to you to help keep your mood within normal limits by helping to control the episodes of mania. Depakote ER allows for once-daily dosing, and sprinkle capsules allow Depakote to be mixed into soft food such as applesauce, yogurt, pudding, oatmeal, or ice cream. However, the clinical and neurophysiological features of valproate-induced tremor are still under-investigated Adult Dosing. Depakote is known to interact with 740 drugs, out of which 21 drug interactions are major, 668 drug interactions are moderate, and 51 drug interactions are minor. Adults, aged 18 and above, can take it to prevent migraine. Color: white,blue Shape: oblong Imprint: THIS END UP DEPAKOTE SPRINKLE 125mg. Depakote ER is intended for once-a-day oral administration. Valproic Acid, Total and Free - Valproic acid is used as an anticonvulsant to treat certain types of seizures, to prevent migraine headaches, and to treat various psychiatric illnesses such as bipolar disorder and aggression. Don't suddenly stop taking this medication since it can raise your risk of withdrawal symptoms, including seizures. It is an effective migraine therapy, and some studies show that it may also reduce the frequency and intensity of migraines in children Depakote is occasionally used as an off-label depression therapy. Seroquel is an antipsychotic that helps to calm and relieve psychotic thoughts. remote.dentrix.com Pregnancy Rating: X; Lactation: Use with caution. 3 out of 10 from a total of 57 reviews on Drugs 52% of reviewers reported a positive experience, while 36% reported a negative experience Depakote (Divalproex) is an anticonvulsant used to prevent seizures. Depakote ER is intended for once-a-day oral administration. Find out how it can help you manage your symptoms. Check depakotewert. I'm just starting out, but I'm up to 1000mg/day of the ER form taken in the morning as instructed. Advertisement It's become an evergreen piece of advice for as. Uncontrolled eye movement. Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. La posologie sera ensuite augmentée aussi rapidement que possible, pour atteindre la dose minimale efficace. Valproic acid is a broad-spectrum antiseizure drug with a narrow therapeutic window. Depakote ER User Reviews & Ratings Depakote ER has an average rating of 7. Fifth month medication was been changed to topamax. Side effects of taking valproic acid can include drowsiness, headaches, rashes, and constipation [2]. Depakote should be swallowed whole and should not be crushed or chewed (22). I have been on Depakote since then;1000MG time release in the evening and 750MG every morning ALONG with mexiletine twice a day and gabapentin in the evening I take four pills. This medication is used to treat seizure disorders, mental/mood conditions (such as manic phase of bipolar disorder ), and to prevent migraine headaches. These symptoms may appear in varying combinations and levels of. Psychosis may pose a greater challenge than cognitive decline for patients with dementia and their caregivers. Typical symptoms of mania include pressure of speech, motor hyperactivity, Depakote and Depakote ER have the potential to cause birth defects. Depakote Sprinkles 125 mg capsule,delayed release Color: white,blue Shape: oblong Imprint: THIS END UP DEPAKOTE SPRINKLE 125mg This medicine is a white blue, oblong, capsule imprinted with "THIS. Save. a NS Pill - pink oval, 19mm.
Depakote may be used to treat certain types of seizure disorder, reduce mania in people with bipolar disorder, and as a preventive treatment for migraines. Applies to: buspirone and Depakote (divalproex sodium) Using busPIRone together with divalproex sodium may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Apr 20, 2024 · Detailed dosage guidelines and administration information for Depakote ER (divalproex sodium). Divide doses >250mg/day. Learn about its dosage, interactions, side effects, warnings, and alternatives from GoodRx. Gastric lavage, activated charcoal, laxative. cars fsbo Depakote 500 Tablet is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses which cause the seizures. Depakote (divalproex) is a prescription medication used to manage certain types of seizures, but it also has a special use if you have bipolar disorder. A few other medicines also become valproate, so their effects are virtually identical. I also take Seroquel with the Depakote at bedtime because I have a sleep disorder as well and this has worked great for the last 8 years. costco gas price pharr tx Valproic acid is a broad-spectrum antiseizure drug with a narrow therapeutic window. Find information on Valproates (Depakote, Depacon) in Davis's Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Alcohol can increase the nervous system side effects of divalproex sodium such as dizziness, drowsiness, and difficulty concentrating. Sudden and severe stomach pain, nausea, vomiting, lightheadedness. Track the interplay of people and communities with scie. randy kay youtube Ordinarily, optimal clinical response is achieved at daily doses below 60 mg/kg/day. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling) Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. O Depakote, ou Divalproato de Sódio, foi inventado para epilepsia, mas também é muito utilizado em casos de bipolaridade e enxaqueca. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Valproate semisodium can also be prescribed to help prevent migraines. DEPAKOTE® (divalproex sodium) delayed-release tablets and DEPAKOTE® ER (divalproex sodium) extended-release tablets are prescription medicines used: alone or with other medicines to treat: - complex partial seizures in adults and children 10 years of age and older. Includes dose adjustments, warnings and precautions.
2003 Winter;66(4):358-91521/psyc425444. Depakote 500 mg tablet,delayed release. On depakote for 3 years. The discontinuation schedule is the plan of how you will decrease the amount of a med you will take. with other medications to treat: Depakote Sprinkle Capsules, for oral use, is a prescription medicine used alone or with other medicines to treat: Depakote products are thought to work by increasing the amount of gamma-aminobutyric acid (GABA) in the brain. DEPAKINE appartient à une famille de médicaments appelés antiépileptiques. Minimum prescription requirement of 30 days supply and/or 30 pills to redeem coupon. at include absence seizuresDepakote ER tablets and Depakote delayed-release. Depakote may help with depression in bipolar disorder. Depakote ER (en español) Play pronunciation. (See below for more information. A manic episode is a distinct period of abnormally and persistently elevated, expansive, or irritable mood. Multi-ingredient medications may also be listed when applicable. toyota tacoma 4x4 used near me A magnetic resonance imaging (MRI) scan of the sinuses creates detailed pictures of the air-filled spaces inside the skull. If you take both medications together, tell your doctor if. This includes aspirin, estrogen-containing birth control pills, and warfarin. Depakote may help with depression in bipolar disorder. Divide doses >250mg/day. LAMICTAL (lamotrigine), an AED of the phenyltriazine class, is chemically unrelated to existing AEDs. Pharmacology, adverse reactions, warnings, and DEPAKOTE ERside effects. 4 out of 10 from a total of 98 ratings on Drugs 65% of reviewers reported a positive effect, while 12% reported a negative effect. • Mania: Initial dose is 750 mg daily, increasing as rapidly as possible to achieve therapeutic response or desired plasma level (2 The maximum recommended dosage is 60 mg/kg/day (22). Dosis dapat ditingkatkan sebanyak 5-10 mg/kgBB per minggu. 5 half lives for a drug to get out of your system. Additional Information. feeling of warmth or heat. Includes dose adjustments, warnings and precautions. natsu x harem fanfiction 1 In an earlier review, Binek and colleagues 2 reported a risk of 1:5000 to 1:10,000 of liver failure with VPA. Depakote (divalproex sodium) is a valproate and is indicated for the treatment of the manic episodes associated with bipolar disorder. It's available in delayed-release tablets, extended-release tablets, and sprinkle capsules. Depakote has an average rating of 6. The effect of VPA on excitatory neurotransmission and on excitatory membranes are mechanisms likely to be responsible for the 'mood-stabilizing' effect as well as in the treatment of migraine. It is sometimes used in conjunction with other seizure medications. Depakote should be taken exactly as prescribed by a physician. Some people may also experience impairment in thinking and judgment. Depakene NO es compatible durante el embarazo de ninguna manera, ya que puede causar daños graves al bebé, por ejemplo malformaciones que alteran su cerebro y sistema nervioso, de acuerdo a los datos que se tienen de mujeres gestantes que han utilizado ácido valproico publicados por medicamentosplm; Depakene puede ser utilizado durante la lactancia si el médico lo considera necesario. Feeling cold/shivering Loss of consciousness. Depakote is a major advance in the treatment of manic episodes associated with bipolar disorder. 93mg sodium (main component of cooking/table salt) in each tablet. Learn how bail works, how to pay for bail and what a bail bondsman is. feeling of warmth or heat. Please see Important Safety Information & Boxed Warning Use & Important Safety Information Depakote is a brand (trade) name for divalproex sodium. It is a mixture of two similar ingredients - valproic acid and sodium valproate. Mania: Initial dose is 25 mg/kg/day, increasing as rapidly as possible to achieve therapeutic response or desired plasma level ( 2The maximum recommended dosage is 60 mg/kg/day ( 22). with other medications to treat: Depakote (divalproex sodium).